Since it was launched in 1996, RestylaneŽ has undergone extensive histological and clinical studies with an increasing body of evidence relating to its ease of use, tolerability and effectiveness. Today, more than one million treatments have been successfully carried out worldwide.

INDICATION

RestylaneŽ is indicated for the correction of moderate to severe
facial wrinkles and folds, such as nasolabial folds, the lines between the nose and mouth.

EFFICACY

In a random, double-blind clinical trial, RestylaneŽ showed a
statistically significant difference over bovine collagen (56.9 percent versus 9.5 percent, respectively) with respect to change from baseline when used to correct nasolabial folds. In addition, these results were sustained more than six months, significantly longer than collagen.

SAFETY

RestylaneŽ is biocompatible and biodegradable since it is made of hyaluronic acid, which naturally exists in the human body. RestylaneŽ has been used by dermatologists and cosmetic surgeons in more than one million procedures in more than 60 countries outside of the United States since 1996.

In clinical studies, the most commonly reported adverse events were redness and swelling, which typically occurred at the injection site and were transient and mild to moderate in intensity.